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Testing for infections during pregnancy
Pregnancy

Testing for infections during pregnancy

2 min readWeek 27
Key takeaways
2 min
  • Expect repeat STI testing in your third trimester even if first trimester results were negative due to incubation periods and potential new infections.
  • Understand that HIV, Hepatitis B, Hepatitis C, and syphilis are routinely screened to prevent serious complications like brain damage and blindness in babies.
  • Know that TORCH testing (toxoplasmosis, rubella, cytomegalovirus, herpes) is only performed when specific symptoms or exposures occur during pregnancy.
  • Discuss false negative and false positive rates with your healthcare provider to understand your test results accurately.
  • Follow your doctor's treatment recommendations carefully, as they balance infection risks against potential medication effects on your baby.

Pregnancy tests for infections include STI screening (HIV, Hepatitis B/C, syphilis) typically repeated in the third trimester, and TORCH testing when indicated. These tests detect infections that can cause serious complications like brain damage, blindness, or developmental issues in babies.

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When you’re expecting, your doctors seem to test for everything. Any little thing they find is cured or treated. But when you reach your third trimester, they sometimes want to test you again, even when your results were negative in the first trimester. What’s going on?

Sexually transmitted infection (STI) tests

STIs can pose a serious risk to baby, including brain damage, blindness, deafness, and pneumonia [1]. The infections most commonly screened are:

  • HIV;

  • Hepatitis B;

  • Hepatitis C;

  • Syphilis.

False negatives aren’t unusual in testing. For example, HIV has an incubation period of up to a year, and hepatitis B, up to nine weeks, leading your test to come back negative during that incubation period [2]. Antibodies might not be detected during the first test. And of course, you can become newly infected during pregnancy, too.

For these reasons, it’s best practice to re-test in the third trimester. Knowledge about an STI will allow you to take the necessary precautions to protect yourself and baby.

TORCH

TORCH stands for toxoplasmosis, other (a disease such as syphilis, varicella, HIV, mumps, or parvovirus), rubella, cytomegalovirus, and herpes simplex. This group of diseases can be dangerous for baby’s development, as he can contract them in utero [3].

There is no need to test for TORCH unless you have a reason to investigate, such as a herpes outbreak during pregnancy. False positives are relatively common. Treatment will vary by infection and individual, as your doctor will make sure the treatment is not potentially more harmful to baby than the infection itself.

Frequently asked questions

Third trimester infection testing is necessary because some infections have long incubation periods and may not show up in early pregnancy tests. You can also contract new infections during pregnancy that need to be detected before delivery.

Standard STI tests during pregnancy include HIV, Hepatitis B, Hepatitis C, and syphilis screening. These infections can cause serious complications for babies including brain damage, blindness, and pneumonia.

TORCH stands for toxoplasmosis, other infections, rubella, cytomegalovirus, and herpes simplex. This testing is only done when there's a specific reason to investigate, such as symptoms or known exposure.

Yes, both false negatives and false positives can occur with pregnancy infection tests. False negatives are common due to incubation periods, while TORCH tests may have false positives.

Pregnancy infection tests are blood tests that are completely safe for both mother and baby. Early detection of infections allows for proper treatment to protect your baby's health.

Medical Disclaimer

This article is for informational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or qualified health provider with any questions you may have regarding a medical condition.

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Medically reviewed content

Reviewed by healthcare professionals · Updated March 25, 2025

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