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Aging of the placenta
Pregnancy

Aging of the placenta

3 min readWeek 31
Key takeaways
3 min
  • Understand that placental aging, now called 'premature maturation,' occurs when the placenta fails to function properly before your baby is ready to be born.
  • Know that normal placental maturity follows stages: first degree by week 31, second degree by week 36, and third degree by week 38.
  • Recognize that early placental aging after 20 weeks can lead to growth restrictions, premature birth, and oxygen deprivation for your baby.
  • Work closely with your healthcare provider for monitoring if diagnosed, as the condition cannot be reversed but complications can be managed.
  • Monitor blood pressure and blood sugar levels carefully, as gestational conditions may be linked to premature placental aging.

Placental aging, now called premature maturation, occurs when the placenta shows dysfunction before baby's birth. Signs include calcification and blood clots detected via ultrasound. While not reversible, careful monitoring can manage complications and protect both mother and baby.

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The diagnosis "aging of the placenta" was widely used in the 1990s and early 2000s, and it caused concern among doctors and expectant mothers. The term has been replaced with “premature maturation” or “dysfunction” of the placenta. By whatever name you use, this is a condition when the placenta fails to perform some of its functions before the baby is ready to be born.

How do doctors determine aging of the placenta?

Signs of aging are most often found on ultrasound in the third trimester. These ultrasounds are usually only prescribed for women at risk during weeks 30–34. As with any organ, the signs of aging are very diverse. Most often doctors may note thrombosis and vascular calcification. Sometimes there is premature cell death, dehydration, thinning (and, less often, thickening) of the placenta [1]. The production of hormones is also disrupted [2].

In general, aging placenta are normal. After all, you only need this organ for the duration of the pregnancy. But if the signs of aging appear long before the due date, then it is considered abnormal.

When might a doctor see signs of an aging placenta?

Twenty weeks is considered a critical point in the management of pregnancy. After this point, if any diseases develop they are labeled "gestational," meaning associated with pregnancy. These diseases include gestational diabetes, gestational hypertension, gestational pyelonephritis and preeclampsia. There is a theory linking the development of all these complications with premature aging of the placenta [3]. That is, if in the 20th week the placenta has reached the first stage of maturity, this is already a cause for concern.

What are the stages of maturity of the placenta?

This is a conditional graph of changes that makes it possible to understand whether the state of the placenta corresponds to the gestational age. On average, the placenta normally reaches:

  • the first degree of maturity by the 31st week;

  • second degree by the 36th week;

  • third degree by the 38th week [4].

Why is early aging of the placenta dangerous for baby?

The placenta is the connecting organ between mom and baby. Thanks to the placenta, a baby receives oxygen and nutrients. If a significant part of the vessels of the placenta is blocked by thrombi or calcifications, then the supply is disturbed, which can lead to slowing of intrauterine growth [5].

Due to a lack of nutrition, babies are born prematurely, and due to oxygen deprivation, serious brain damage is possible. Most cases of cerebral palsy are associated with a malfunction of the placenta [1].

What should I do with this diagnosis? Is it being treated?

Aging is a one-way process and cannot be reversed. But with aging of the placenta, things are about the same as with normal aging: you can delay or compensate for the diseases associated with it. Therefore, if a problem is identified, then doctors will closely monitor both mother and baby [1, 3]. It is important to keep blood pressure, blood sugar levels under control and monitor urine protein.


Frequently asked questions

Placental aging, now called premature maturation, occurs when the placenta shows signs of dysfunction before your baby is ready to be born. This includes calcification, blood clots, and hormonal disruption that can affect your baby's oxygen and nutrient supply.

Placental aging becomes concerning when signs appear before 20 weeks or when maturity stages occur too early. If first-degree maturity occurs before week 31, this may indicate premature aging that requires monitoring.

Placental aging cannot be reversed, but complications can be managed through close monitoring. Your doctor will track blood pressure, blood sugar, and your baby's growth to prevent serious complications.

Placental aging can reduce oxygen and nutrient supply to your baby, potentially causing growth restrictions, premature birth, or brain damage. Most cases are manageable with proper medical monitoring and care.

Doctors detect placental aging through ultrasounds, typically performed between weeks 30-34 for at-risk pregnancies. They look for calcification, blood clots, cell death, and changes in placental thickness.

Medical Disclaimer

This article is for informational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or qualified health provider with any questions you may have regarding a medical condition.

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Reviewed by healthcare professionals · Updated March 25, 2025

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